If you’re looking for a good program to help you clean out the Vista registry then I highly recommend checking out RegCure.  RegCure is hands down the best registry cleaner for Vista available. 

Cleaning out the Vista registry allows you to streamline your computer so that you can more easily run software and hardware.  There are several reasons to clean the registry.  The registry tends to get overfilled with temporary and obsolete files. This can cause your computer to bog down.  Instability issues often arise from registry errors and corruption as well.  Using a registry cleaner is a safe and easy way to get your computer running well.